ea0086p345 | Neuroendocrinology and Pituitary | SFEBES2022
Urbanski Henryk
, Appleman Maria-Luisa
, Nilaver Benjamin
, Kohama Steven
Amyloid beta (Aβ) plaques represent one of the classic hallmarks of Alzheimers disease (AD) pathology in the brain. In rhesus macaques, these plaques start becoming prominent when the animals are 20+ years old, although the underlying cause(s) are unclear. In the present study, our goal was to test the hypothesis that exposure to a Western-style, high-fat, high-sugar diet (WSD) and/or loss of ovarian steroids would advance the development of this histological marker...